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Prototype Prescribing Outlier Dashboard for Luson

At OpenPrescribing we are piloting a number of data-driven approaches to identify unusual prescribing and collect feedback on this prescribing to inform development of new tools to support prescribers and organisations to audit and review prescribing. These pilot results are provided for the interest of advanced users, although we don't know how relevant they are in practice. There is substantial variation in prescribing behaviours, across various different areas of medicine. Some variation can be explained by demographic changes, or local policies or guidelines, but much of the remaining variation is less easy to explain.

The DataLab is keen to hear your feedback on the results. You can do this by completing the following survey or emailing us at [email protected]. Please DO NOT INCLUDE IDENTIFIABLE PATIENT information in your feedback. All feedback is helpful, you can send short or detailed feedback.

This report has been developed to automatically identify prescribing patterns at a chemical level which are furthest away from “typical prescribing” and can be classified as an “outlier”. We calculate the number of prescriptions for each chemical in the BNF coding system, the count of all prescriptions within that chemical's BNF subparagraph, for prescriptions dispensed between June 2021 and December 2021. We then calculate the ratio of these counts along with the mean and standard deviation of those ratios across all Practices. From this we can calculate the “z-score”, which is a measure of how many standard deviations a given Practice is from the population mean. We then rank your “z-scores” to find the top 10 results where prescribing is an outlier for prescribing higher than its peers and those where it is an outlier for prescribing lower than its peers.

For each outlier chemical, a kernel density estimation plot of all Practice's chemical:subparagraph ratios is provided, with this Practice's ratio overlaid in red.

It is important to remember that this information was generated automatically and it is therefore likely that some of the behaviour is warranted. This report seeks only to collect information about where this variation may be warranted and where it might not, to inform research on this topic. Our full analytical method code is openly available on GitHub here.

This is a new, experimental feature. We'd love to .

Prescribing where Luson is higher than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Methenamine hippurate 146 Urinary-tract infections 335 0.44 0.04 0.06 6.75
Aclidinium bromide 139 Antimuscarinic bronchodilators 409 0.34 0.04 0.07 4.46
Undecenoates 4 Antifungal preparations 135 0.03 0.00 0.01 4.37
Ciclosporin (Eye Anti Inflammatory) 13 Other anti-inflammatory preparations 33 0.39 0.07 0.08 4.00
Bupropion hydrochloride 31 Nicotine dependence 33 0.94 0.16 0.25 3.09
Magnesium hydroxide 1 Antacids and simeticone 2 0.50 0.03 0.15 3.05
Phentolamine/aviptadil 4 Drugs for erectile dysfunction 303 0.01 0.00 0.00 3.00
Pentoxifylline 2 Peripheral vasodilators and related drugs 2 1.00 0.15 0.30 2.88
Salicylic acid 1 Preparations for psoriasis 40 0.02 0.00 0.01 2.71
Triptorelin 40 Prostate cancer and gonadorelin analogues 79 0.51 0.09 0.16 2.70

Prescribing where Luson is lower than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Nitrofurantoin 189 Urinary-tract infections 335 0.56 0.96 0.06 -6.74
Fusidic acid 14 Antibacterial preparations also used systemically 37 0.38 0.75 0.14 -2.61
Tacrolimus 1 Drugs affecting the immune response 3 0.33 0.81 0.19 -2.43
Mercaptopurine 0 Antimetabolites 40 0.00 0.80 0.35 -2.32
    Alfentanil hydrochloride 0 Opioid analgesics 2 0.00 0.82 0.38 -2.18
      Acamprosate calcium 1 Alcohol dependence 6 0.17 0.83 0.31 -2.15
      Simvastatin 327 Lipid-regulating drugs 5,272 0.06 0.22 0.07 -2.07
      Trimethoprim 73 Sulfonamides and trimethoprim 117 0.62 0.87 0.12 -2.01
      Nicotine 0 Nicotine dependence 33 0.00 0.65 0.33 -1.95
        Neomycin sulfate 16 Nasal preparations for infection 28 0.57 0.84 0.14 -1.94