Items which should not routinely be prescribed in primary care - minocycline

Below are the database queries which are used to create this measure. These are run against a copy of the BSA prescribing data which we store in Google BigQuery. We're working on making our BigQuery tables publicly available at which point it will be possible to run and modify these queries yourself. But even where code and database queries are not directly useable by others we believe it is always preferable to make them public.

Description Minocycline per 1000 patients
Why it matters

NHS England guidance states

Minocycline is a tetracycline antibiotic that can be used for many indications. In primary care it is mainly used for acne. There are various safety risks associated with its use.

NICE guidance on acne vulgaris management advises: 'Minocycline is not recommended for use in acne as it is associated with an increased risk of adverse effects such as drug-induced lupus, skin pigmentation and hepatitis.'

A PrescQIPP CIC review found no evidence to support the use of one tetracycline over another in terms of efficacy for the treatment of acne vulgaris, and alternative once daily products are available.

NHS England recommend that GPs:

  • Do not initiate.
  • Deprescribe in patients currently prescribed this medicine.
Tags Antimicrobial Stewardship, Cost Saving, NHS England - items which should not routinely be prescribed in primary care, NICE, Safety
Implies cost savings Yes
Authored by richard.croker
Checked by christopher.wood
Last reviewed 2023-09-18
Next review due 2025-09-18
History View change history on GitHub →

Numerator SQL

     CAST(month AS DATE) AS month,
     practice AS practice_id,
     SUM(actual_cost) AS numerator
 FROM hscic.normalised_prescribing
 WHERE bnf_code IN ("0501030P0AAAAAA", "0501030P0AAABAB", "0501030P0AAACAC", "0501030P0AAADAD", "0501030P0AAAEAE", "0501030P0BBACAC", "0501030P0BDABAE", "0501030P0BHAAAC", "0501030P0BHABAC")
 GROUP BY month, practice_id

Denominator SQL

     CAST(month AS DATE) AS month,
     practice AS practice_id,
     SUM(total_list_size / 1000.0) AS denominator
 FROM hscic.practice_statistics
 GROUP BY month, practice_id