Why it matters:
The tricyclic antidepressant (TCA) trimipramine is significantly more expensive than other antidepressants.
NICE guidance on depression in adults recommends selective serotonin reuptake inhibitor (SSRI) antidepressants first line if indicated as they have a more favourable risk-to-benefit ratio compared to TCAs. However, if a TCA is required, more cost-effective TCAs than trimipramine are available.
Due to the significant cost associated with trimipramine and the availability of alternative treatments, the joint clinical working group considered trimipramine suitable for inclusion in this guidance.
NHS England recommend that GPs:
Description: Cost of trimipramine per 1000 patients
Sub-ICB Locations are ordered by mean percentile over the past six months. Each chart shows the results for the individual Sub-ICB Location, plus deciles across all Sub-ICB Locations in the NHS in England.